Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach.

نویسندگان

  • Shigeo Masuda
  • Jun Wu
  • Tomoaki Hishida
  • Ganesh N Pandian
  • Hiroshi Sugiyama
  • Juan Carlos Izpisua Belmonte
چکیده

Induced pluripotent stem cells (iPSCs) could be generated by a single gene Oct4 and chemical compounds, in which exogenous expression of Oct4 was indispensable for reprogramming. Recent advances in chemical-mediated cellular reprogramming suggest that small molecules alone (i.e. without Yamanaka factors) can successfully establish iPSCs from mouse somatic cells.

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عنوان ژورنال:
  • Journal of molecular cell biology

دوره 5 5  شماره 

صفحات  -

تاریخ انتشار 2013